Salivary Protein Card
Accession: Sp001437 Uncharacterized protein Dmel_CG42637, isoform C [Drosophila melanogaster]
Basic info
| Organism | Drosophila melanogaster |
| Taxonomy | Insecta > Diptera > Drosophilidae > Drosophila > Drosophila melanogaster |
| Protein Description | Uncharacterized protein Dmel_CG42637, isoform C |
| Mass Weight | 170501.433 |
| Isoelectric Point | 6.825 |
Annotation
| Function | Guanylate cyclase involved in the production of the second messenger cGMP (PubMed:24284209). Acts as a receptor for the NPLP1-4 peptide and modulates the inte immune IMD pathway in response to salt stress by inducing nuclear translocation of NF-kappa-B protein Rel which leads to increased expression of the antimicrobial peptide diptericin (PubMed:21893139). Plays a role in Sema-1a-mediated axon repulsion which is required for the correct establishment of neuromuscular connectivity (PubMed:15282266, PubMed:24284209). Required in developing embryonic somatic muscle for correct patterning of ventral and lateral muscles and for localization of integrin beta-ps at developing dorsal muscle myotendinous junctions (PubMed:23213443). Required for invagition, migration and lumen shape of the embryonic salivary gland by regulating the localization of the integrin-binding protein rhea/Talin to the visceral mesoderm surrounding the gland and maintaining the laminin matrix (PubMed:23862019). Required in the developing wing to regulate extracellular matrix (ECM) organization by activating the cGMP-dependent protein kise For which represses the activity of matrix metalloproteases such as Mmp2 and decreases ECM matrix reorganization (PubMed:26440503). | ||
| Pfam |
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Features
| Feature key | Position | Length |
| Signal Peptide | 1-21 | 21 |
| Chain | 22-1525 | 1504 |
Sequence
3D Structure
Not available now!
Publication
| 1. |
Fasano L, R?der L, Cor N, Alexandre E, Vola C, Jacq B, Kerridge S.; The gen teashirt is required for the development of Drosophila embryonic trunk segment and encodes a protein with widely spaced zinc finger motifs.; Cell. 1991 Ja 11;64(1):63-79. |