Salivary Protein Card
Accession: Sp001464 Warts [Drosophila melanogaster]
Basic info
| Organism | Drosophila melanogaster |
| Taxonomy | Insecta > Diptera > Drosophilidae > Drosophila > Drosophila melanogaster |
| Protein Description | Warts |
| Mass Weight | 122487.047 |
| Isoelectric Point | 9.427 |
Annotation
| Function | Negative regulator of Yorkie (Yki) in the Hippo/SWH (Sav/Wts/Hpo) sigling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kise cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and ictivates the Yorkie (Yki) oncoprotein. The Hippo/SWH sigling pathway inhibits the activity of the transcriptiol complex formed by Scalloped (sd) and Yki and the target genes of this pathway include cyclin-E (cycE), diap1 and bantam. Inhibits nuclear localization of Yki. Regulates salivary gland degradation in a PI3K-dependent manner and Yki- and Sd-independent, mechanism. | ||
| Pfam |
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Features
| Feature key | Position | Length |
| Chain | 1-1105 | 1105 |
Sequence
3D Structure
Not available now!
Publication
| 1. |
Sekelsky JJ, Newfeld SJ, Raftery LA, Chartoff EH, Gelbart WM.; Geneti characterization and cloning of mothers against dpp, a gene required fo decapentaplegic function in Drosophila melanogaster.; Genetics. 199 Mar;139(3):1347-58. |