Salivary Protein Card
Accession: Sp001536 Rho1, isoform A [Drosophila melanogaster]
Basic info
| Organism | Drosophila melanogaster |
| Taxonomy | Insecta > Diptera > Drosophilidae > Drosophila > Drosophila melanogaster |
| Protein Description | Rho1, isoform A |
| Mass Weight | 21722.932 |
| Isoelectric Point | 6.614 |
Annotation
| Function | Has a role in regulating actin cytoskeletal organization: required during early development for proper execution of morphogenetic movements of individual cells and groups of cells important for the formation of the embryonic body plan (PubMed:10556060, PubMed:24535826, PubMed:25739458). Plays a role in regulating dorsal closure during embryogenesis (PubMed:10556060, PubMed:10323867). During axis elongation, required for Rho-kise Rok plar polarity and adherens junction localization as well as for generating a plar polarized distribution of the actin-binding protein Shrm (PubMed:24535826). During embryogenesis, acts upstream of wash to regulate the developmental migration of tail hemocytes anteriorly along the ventral midline (PubMed:25739458). May have a role in eye development (PubMed:7835340). | ||
| Pfam |
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Features
| Feature key | Position | Length |
| Chain | 1-192 | 192 |
Sequence
3D Structure
Not available now!
Publication
| 1. |
Hariharan IK, Hu KQ, Asha H, Quintanilla A, Ezzell RM, Settleman J.; Characterization of rho GTPase family homologues in Drosophila melanogaster: overexpressing Rho1 in retil cells causes a late developmental defect.; EMBO J. 1995 Jan 16;14(2):292-302. |