Salivary Protein Card
Accession: Sp001589 Nitrophorin-7 [Rhodnius prolixus]
Basic info
| Organism | Rhodnius prolixus |
| Taxonomy | Insecta > Hemiptera > Reduviidae > Rhodnius > Rhodnius prolixus |
| Protein Description | Nitrophorin-7 |
| Mass Weight | 22900.991 |
| Isoelectric Point | 8.838 |
Annotation
| Function | Converts nitrite as the sole substrate to form nitric oxide gas (NO). NO(2-) serves both as an electron donor and as an electron acceptor. Binds to negatively charged cell surfaces of activated platelets; binds to L-a-phosphatidyl-L-serine (PS)-bearing phospholipid membranes. Once bound on an activated platelet, NP7 releases its stored nitric oxide gas (NO) into the victims tissues while feeding, resulting in vasodilation and inhibition of platelet aggregation. Also acts as an anticoagulant by blocking coagulation-factor binding sites. Has antihistamine activity; binds histamine with high affinity. | ||
| Pfam |
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Features
| Feature key | Position | Length |
| Signal Peptide | 1-20 | 20 |
| Chain | 21-205 | 185 |
Sequence
3D Structure
Not available now!
Publication
| 1. |
Andersen JF, Gudderra NP, Francischetti IM, Valenzuela JG, Ribeiro JM.; Recognition of anionic phospholipid membranes by an antihemostatic protein from a blood-feeding insect.; Biochemistry. 2004 Jun 8;43(22):6987-94. |