Salivary Protein Card
Accession: Sp001597 Moricin [Manduca sexta]
Basic info
| Organism | Manduca sexta |
| Taxonomy | Insecta > Lepidoptera > Sphingidae > Manduca > Manduca sexta |
| Protein Description | Moricin |
| Mass Weight | 7205.644 |
| Isoelectric Point | 10.889 |
Annotation
| Function | Antimicrobial peptide. Active against a broad spectrum of Gram-positive and Gram-negative bacteria including methicillin-resistant S.aureus ATCC 43 300, S.aureus BAA-39, pathogenic strains of L.monocytogenes, K.pneumoniae, E.coli O157:H7, S.typhimurium and multidrug-resistant S.typhimurium DT104 with minimum inhibitory concentration (MIC) of 1.4 uM for all except for S.aureus BAA-39 (PubMed:18265434). Also active against Serratia marcescens (PubMed:14728663). Probably acts by disturbing membrane functions with its amphipathic alpha-helical structure (PubMed:18265434). May protect a developing embryo from bacterial infection (Probable). | ||
| Pfam |
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Features
| Feature key | Position | Length |
| Signal Peptide | 1-23 | 23 |
| Chain | 24-67 | 44 |
Sequence
3D Structure
Not available now!
Publication
| 1. |
Zhu Y, Johnson TJ, Myers AA, Kanost MR.; Identification by subtractive suppression hybridization of bacteria-induced genes expressed in Manduca sexta fat body.; Insect Biochem Mol Biol. 2003 May;33(5):541-59. |