Salivary Protein Card
Accession: Sp001600 Defensin Lucifensin [Lucilia sericata]
Basic info
| Organism | Lucilia sericata |
| Taxonomy | Insecta > Diptera > Calliphoridae > Lucilia > Lucilia sericata |
| Protein Description | Defensin Lucifensin |
| Mass Weight | 9995.535 |
| Isoelectric Point | 8.214 |
Annotation
| Function | Shows strong antibacterial activity against numerous Gram-positive bacteria. It selectively inhibits peptidoglycan biosynthesis through complex formation with the cell wall precursor lipid II (1:1 molar ratio) thus inhibiting cell wall synthesis (PubMed:20508130). Shows antibacterial activity against the Gram-positive bacteria M.luteus, E.fecalis (MIC=32 mg/L), S.aureus (MIC=16 mg/L), S.carnosus (MIC=2 mg/L), S.pneumoniae (MIC=2 mg/L) and S.pyogenes (MIC=2 mg/L) and against a number of methicillin-resistant S.aureus and glycopeptide-intermediate S.aureus isolates (PubMed:20542901, PubMed:19921400, PubMed:21560219). Does not show antibacterial activity against Gram-negative bacteria or antifungal activity against C.utilis (PubMed:20542901). Shows slight antifungal activity against C.albicans (PubMed:21560219). | ||
| Pfam |
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Features
| Feature key | Position | Length |
| Signal Peptide | 1-23 | 23 |
| Chain | 24-92 | 69 |
Sequence
3D Structure
Not available now!
Publication
| 1. |
Andersen AS, Sandvang D, Schnorr KM, Kruse T, Neve S, Joergensen B, Karlsmark T, Krogfelt KA.; A novel approach to the antimicrobial activity of maggot debridement therapy.; J Antimicrob Chemother. 2010 Aug;65(8):1646-54. 20542901 |