Salivary Protein Card
Accession: Sp001612 Tyrosine-protein kise Src42A [Drosophila melanogaster]
Basic info
| Organism | Drosophila melanogaster |
| Taxonomy | Insecta > Diptera > Drosophilidae > Drosophila > Drosophila melanogaster |
| Protein Description | Tyrosine-protein kise Src42A |
| Mass Weight | 59068.69 |
| Isoelectric Point | 6.234 |
Annotation
| Function | Required directly or indirectly for the phosphorylation of drpr which is necessary for the interaction of drpr with shark and subsequent glial phagocytic activity (PubMed:18432193). Together with drpr and shark, promotes the migration of macrophages to sites of wounding as part of a sigling cascade where Scr42a detects production of hydrogen peroxide at wound sites which triggers phosphorylation of drpr and subsequent recruitment and activation of shark (PubMed:26028435). Essential for correct eye morphogenesis (ommatidial R7 neuron formation) which requires the Ras1/MAPK sigl transduction pathway (PubMed:8682295). May be involved in the regulation of cytoskeleton organization and cell-cell contacts in developing ommatidia (PubMed:8682295). During embryogenesis, involved in regulation of dorsal closure where it may have a role in activating the JNK pathway in leading edge cells during this process (PubMed:16831834). | ||
| Pfam |
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Features
| Feature key | Position | Length |
| Chain | 1-517 | 517 |
Sequence
3D Structure
Not available now!
Publication
| 1. |
Takahashi F, Endo S, Kojima T, Saigo K.; Regulation of cell-cell contacts in developing Drosophila eyes by Dsrc41, a new, close relative of vertebrate c-src.; Genes Dev. 1996 Jul 1;10(13):1645-56. |