Salivary Protein Card
Accession: Sp001616 Ras-related protein Rab6 [Drosophila melanogaster]
Basic info
| Organism | Drosophila melanogaster |
| Taxonomy | Insecta > Diptera > Drosophilidae > Drosophila > Drosophila melanogaster |
| Protein Description | Ras-related protein Rab6 |
| Mass Weight | 23480.205 |
| Isoelectric Point | 5.215 |
Annotation
| Function | Protein transport (PubMed:17329360, PubMed:17827179, PubMed:18833296, PubMed:21835342, PubMed:22928698, PubMed:33704067, PubMed:9685396). Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER) (PubMed:21795785). Mediates membrane trafficking during egg chamber growth and organization, possibly upstream of exocyst component Sec5. Also during oogenesis, plays a role, together with BicD but independently of Sec5, in the polarization of the oocyte microtubule cytoskeleton, in the localization of oskar mR and in the anterodorsal secretion of grk. Required for anterograde opsin transport through the ER-Golgi complex. Plays a role, together with Rich, in regulating CadN transport in photoreceptor cells which is required for the formation of normal syptic connections between axons from the inner photoreceptor cells in the eye and postsyptic cells in the brain medulla layer M6 (PubMed:21835342). Necessary for proper development of bristle shafts of macrochaete and microchaete on the head, thorax and scutellum. Modulates Notch sigling (PubMed:10459009). As a key regulator of vesicular traffic, plays a critical role in the regulation of actin organization and is required for normal rates of phagocytic uptake during phagocytosis involved in defense against viral and fungal infection. | ||
| Pfam |
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Features
| Feature key | Position | Length |
| Chain | 1-208 | 208 |
Sequence
3D Structure
Not available now!
Publication
| 1. |
Satoh AK, Tokuga F, Ozaki K.; Rab proteins of Drosophila melanogaster: novel members of the Rab-protein family.; FEBS Lett. 1997 Mar 3;404(1):65-9. |