Salivary Protein Card
Accession: Sp001617 Ras-related protein Rac1 [Drosophila melanogaster]
Basic info
| Organism | Drosophila melanogaster |
| Taxonomy | Insecta > Diptera > Drosophilidae > Drosophila > Drosophila melanogaster |
| Protein Description | Ras-related protein Rac1 |
| Mass Weight | 21353.688 |
| Isoelectric Point | 8.621 |
Annotation
| Function | During various developmental processes, regulates changes in cell morphology in response to extracellular sigls (PubMed:7958857, PubMed:10323867, PubMed:24855950). During oogenesis, mediates sigling from the tyrosine kise (RTK) chemoattractant receptors (Egfr and Pvr) to the guidance pathway that control the directiol persistent collective migration of the border cell (BC) cluster through the nurse cells to the oocyte. Once activating by Pvr and Egfr, promotes the formation of forward-directed actin protrusions which stabilize the DE-cadherin (shg)-mediated adhesions. In turn, DE-mediated adhesion between the leader border cells and nurse cells further promotes Rac1 sigling creating a positive feedback loop that amplifies the output of RTK activity and leads to higher Rac activity at the front, thus promoting polarization of the border cell cluster and directiolly persistent migration (PubMed:24855950). Involved in axon outgrowth and myoblast fusion (PubMed:7958857). Plays a role in regulating dorsal closure during embryogenesis (PubMed:10323867). Involved in integrin alpha-PS3/beta-nu-mediated phagocytosis of Gram-positive S.aureus by hemocytes (PubMed:22547074). | ||
| Pfam |
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Features
| Feature key | Position | Length |
| Chain | 1-192 | 192 |
Sequence
3D Structure
Not available now!
Publication
| 1. |
Luo L, Liao YJ, Jan LY, Jan YN.; Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axol outgrowth and myoblast fusion.; Genes Dev. 1994 Aug 1;8(15):1787-802. |