iSalivaomicDB

Basic info

Organism	Drosophila melanogaster
Taxonomy	Insecta > Diptera > Drosophilidae > Drosophila > Drosophila melanogaster
Protein Description	Receptor-type guanylate cyclase Gyc76C
Mass Weight	170501.433
Isoelectric Point	6.825

Annotation

Function

Guanylate cyclase involved in the production of the second messenger cGMP (PubMed:24284209). Acts as a receptor for the NPLP1-4 peptide and modulates the inte immune IMD pathway in response to salt stress by inducing nuclear translocation of NF-kappa-B protein Rel which leads to increased expression of the antimicrobial peptide diptericin (PubMed:21893139). Plays a role in Sema-1a-mediated axon repulsion which is required for the correct establishment of neuromuscular connectivity (PubMed:15282266, PubMed:24284209). Required in developing embryonic somatic muscle for correct patterning of ventral and lateral muscles and for localization of integrin beta-ps at developing dorsal muscle myotendinous junctions (PubMed:23213443). Required for invagition, migration and lumen shape of the embryonic salivary gland by regulating the localization of the integrin-binding protein rhea/Talin to the visceral mesoderm surrounding the gland and maintaining the laminin matrix (PubMed:23862019). Required in the developing wing to regulate extracellular matrix (ECM) organization by activating the cGMP-dependent protein kise For which represses the activity of matrix metalloproteases such as Mmp2 and decreases ECM matrix reorganization (PubMed:26440503).

Pfam

PF00211

Guanylate_cyc

Features

Feature key	Position	Length
Signal Peptide	1-21	21
Chain	22-1525	1504

Cross-Reference

NCBI Nucleotide	L35598.1
NCBI Protein	AAA74408.1
UniProt	Q7JQ32

Sequence

CDS[Download]

ATGACGCGTTGGCCCTTTAATCTACTACTCTTGCTGTCGGTGGCGGTACGCGACTGTAGCAATCATCGCACCGTCCTCACTGTCGGCTACCTAACGGCCCTCACTGGCGATCTCAAGACGCGTCAGGGACTGGCCATTTCCGGTGCCCTGACTATGGCCCTGGATGAGGTCAACAAAGATCCCAATCTTCTGCCAAATGTGTACCTGGATCTGCGCTGGAATGACACCAAGGGGGACACGGTACTGGCCACCAAGGCCATCACCGAGATGATATGCGATGGCATCGCCACCATTTTTGGCCCGGAAGGACCTTGCTATGTGGAGGCCATCGTCTCGCAGAGTCGAAACATTCCAATGATTTCCTACAAATGTGCAGAGTACCGTGCATCCGCCATACCGACATTCGCCCGCACCGAGCCGCCAGATACACAGGTCGTTAAGTCGCTGCTTGCCCTTCTGCGATATTATGCGTGGAATAAGTTTTCCATTCTGTACGAGGATGTGTGGAGTCCGGTGGCTGATCTGCTGAAAGATCAGGCCACCAAGAGAAATATGACGATCAACCACAAGCAGTCGTTCATTGATAATCGAGTCAAGTGCTGTGAGCAGATGCTGGACTGCTGTCGTTCTGGGTATTGGTACCAGCTGGTGCAAAACACGATGAATCGCACACGAATCTACGTATTTCTGGGGGCGGCGAATAGTCTGGTGGACTTTATGAGTTCCATGGAGACCGCTGGTCTGTTTGCCCGTGGCGAGTATATGGTGATCTTTGTCGACATGATGGTCTATTCCGAGAGGGAGGCAGAAAAGTACTTGCGCAGAGTGGATCAAATAACATTCATGTCCAATTGCCATAGCACGGAGAACTTCAATCAAATGGCCCGCAGTCTTCTCGTCGTGGCATCCACGCCACCCACAAAGGATTACATACAGTTCACTAAACAAGTGCAGAAGTACAGCTCAAAGCCGCCGTTCAATTTGGAAATTCCCAGGCTGTTTGTAGAAAGTAATTTTAGCAAGTTCATATCGATCTATGCCGCGTACCTGTACGATTCGGTAAAGCTGTATGCCTGGGCTGTGGACAAAATGCTGCGGGAGGAGACCCGAGTCTTGACCGATGATGTGATCTTCGAGGTGGCCAGCAACGGAACACGTGTAATCGATACCATAATCAAAAACCGTACTTATATGAGCATCACTGGATCCAAAATTAAGATCGATCAATATGGCGATTCGGAGGGTAATTTTTCGGTCCTGGCCTACAAGCCACACAAGTGGAATAACTCGAACAACATGCCCTGCAACTATCACATGGTTCCTGTAGCTTACTTTCATCAAGGCGAAGAACATCCAGAGTACAAGCTCATCAATGGCTCCATAGATTGGCCATCGGGCGGTGAGAAGCCCGCAGATGAACCGATGTGCGGTTTTGCAAACGAACTGTGTAAAAAGGACGACACCCACTATACGTCCACTGTCGCCGCTGTGGTTTTGGGCGTATTGCTCTTCTGCTCAGGTGTTATCACCATGAGTATATATCGGAAGTGGAAGATCGAGTTGGAGATTGAGGGCTTACTCTGGAAGATCGACCCGAACGAAATAAAGGGTTATTCTGGCAACGAGATTGTCTCCTCACCGAGCAAAGTCAGTTTGATGAGTGCCCAGAGCTATGGTTCCCGCTGGACCAACCAGTTTGTTACCTCCACGGGTCGCCTTCGCGGGGCCGTGGTTCGTATTAAGGAGTTGAAATTCCCGCGGAAGCGAGACATATCCAGGGAGATCATGAAGGAGATGCGATTGTTGCGCGAACTGCGTCACGATAACATCAACAGCTTCATTGGCGCCAGCGTGGAGCCAACACGCATTCTTCTAGTCACCGATTACTGTGCCAAAGGCAGTCTTTACGACATCATTGAGAACGAGGACATTAAGTTGGACGATCTATTCATCGCCTCGCTTATTCACGACCTCATAAAGGGCATGATCTATATACACAACTCTCAGCTCGTCTATCATGGTAACCTTAAATCCTCAAACTGTGTGGTCACCTCGCGTTGGATGCTCCAAGTCACCGATTTCGGGCTGCACGAGTTGCGGCAGTGTGCCGAAAACGAATCCATCGGGGAGCATCAGCATTATCGAAATCAACTTTGGCGCGCTCCAGAGCTGCTGCGGAATCACATTCACGGCAGCCAGAAGGGCGATGTCTATGCCTTTGCCATCATCATGTACGAGATATTTAGTCGTAAGGGTCCGTTCGGACAAATTAACTTTGAACCAAAGGAAATCGTAGACTATGTCAAGAAGCTGCCGCTCAAGGGAGAGGATCCCTTTCGGCCGGAAGTGGAGTCCATTATAGAGGCCGAGTCCTGTCCGGATTACGTACTGGCCTGCATCAGGGACTGCTGGGCTGAAGATCCCGAAGAGCGGCCCGAATTCAGTGTCATACGCAATCGCTTGAAGAAGATGCGTGGTGGTAAGACCAAGAACATCATGGATCAAATGATGGAAATGATGGAGAAGTATGCCAACAACTTGGAGGACATTGTCACCGAGCGCACGCGTCTCCTGTGCGAGGAAAAGATGAAAACGGAGGATCTCCTGCATCGCATGCTACCGCAATCGGTGGCTGAAAAATTGACCATGGGTCAGGGTGTCGAGCCCGTTTCATATGATTTGGTAACCATATATTTTAGCGACATTGTTGGTTTTACTGCAATGTCGGCGGAGAGCACACCGCTGCAAGTGGTGAACTTTTTGAATGATCTCTACACAGTGTTCGATCGCATCATACGCGGCTATGATGTCTATAAAGTTGAAACCATTGGAGATGCTTACATGGTGGTTTCGGGTCTGCCAATTAAAAACGGAGATCGACATGCAGGCGAGATAGCTTCGATGGCCCTGGAGCTGCTCCACGCTGTCAAGCAGCACCGCATAGCCCATCGTCCCAACGAGACGCTGAAGCTGCGCATTGGGATGCACACGGGTCCGGTGGTAGCGGGCGTGGTTGGTCTCACCATGCCGAGATACTGCCTTTTTGGTGACACCGTGAATACAGCGTCCCGGATGGAGAGCAACGGAGAGGCGCTAAAGATTCACATTTCCAATAAGTGCAAGCTGGCGCTGGACAAACTGGGTGGTGGCTACATAACCGAGAAACGTGGCCTGGTCAATATGAAGGGCAAGGGCGATGTGGTTACTTGGTGGCTAACCGGAGCCAACGAGAATGCTATTCAGAAGAAGTTAGTGGATATGATGGACATGCCGCCGCCGCTGTTTAGTCGTCCTCGAAAGAGTCCAAAGCTAAATCCCGACTCCCGTCAGCCAAGCATCCAGGCCATGCACTTCTGCGGCACCGGATCAAGACGCCAGAGCACAGTTCCCAGGGCGATGGACGGCGAATCAACGTATAGCCTCCAGGGATCCGTGAGGGAATCACCGCGCATGGTCAGCAAACGTGACAGGGATCGAGAGCGACCCCCCATCAATGGACTGGGCGCAGGGCACTTCGTGGGGGGAGCTCTCCTCGAATCCGCACAGGCCTCGCTTAGCACGCTGAATCATTCCGAAACAAACGAAACTAACTGTGATATGGATGGGGGATCGGGAGGAGTGTCAGGATCTGGATCTGGATTAGTGCGTCAACCCAATGCACTGCACAAACCGTTGGCCATGGTGCGGCCGCACCGGATTATTAGTGCTGCCCAGCTACCCCAACTGGGAGATAACGATGATGACTCCGCAGACACGCTGTTGCGGGAGTCTCGCTCCCTGGATCCCATGCCCATGCAGCAACTGCGCAAACGTCACGACAGGGTAAAGTTGCCGCCCTCGAAGTTGTCCAAGAACAATTCCCGATCGCTGGACACGGGTGTATCGCTGATCAGTGGGAATCCCAACGGTGAAGTGCACTCGAGTCAACTGGATTTGGATAACGAGATGACCGCCAACCCGGTGGATGCCACCGATGGCTACGACGATGAGCTGGGCCTTCTGATGCGCCACGACAACGGCCAACTGCCTGCTCTCCGCTATTCAGGCAGCTTTCCCAACGCTCAGATTAGCATTGTTCCTACAGGAAGGTCAGCAGGAGGAGGAGGAGGAGGAAGAGAAGGAGGTGGGAGCAACTGTGCCAAGCATCTGAACAACAACTGCAACGGAGGAGTGAACGTCGAGGATGATCTTGAGTCGCCCCTGCTGCAACGCCAGGCATCGCTGTCGGTGCCGCCAGAGGAGATGCTGGCGCACAACAAACGTTGGCACTCACTGGAGCACATGGATGGTCCCGGTGGGCATGGCGGAAATAGCGTTAGCTATGCCGCCGATATTGATAACCGCCACCCCGGAGATCTGGACTTCTTCAGCGGTTCCTCCAATCAGCATCATAGATCCAAAGCGGCTGGTGGGAGTAAGCTGACTAACTGGATGACTAACATCTTCAAGGGCAACGGCGTGCGTAGCGGTGAGGCTAGGCGAGTAGGAATCCTGCCCAGCGGTGTGCACGGCGCACGAACCGGATTCACGGATATGGCGGCATCGGCAGCAGCCCGCGATCGTGAGAGTATAGTATAG

Protein[Download]

MTRWPFNLLLLLSVAVRDCSNHRTVLTVGYLTALTGDLKTRQGLAISGALTMALDEVNKDPNLLPNVYLDLRWNDTKGDTVLATKAITEMICDGIATIFGPEGPCYVEAIVSQSRNIPMISYKCAEYRASAIPTFARTEPPDTQVVKSLLALLRYYAWNKFSILYEDVWSPVADLLKDQATKRNMTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNTMNRTRIYVFLGAANSLVDFMSSMETAGLFARGEYMVIFVDMMVYSEREAEKYLRRVDQITFMSNCHSTENFNQMARSLLVVASTPPTKDYIQFTKQVQKYSSKPPFNLEIPRLFVESNFSKFISIYAAYLYDSVKLYAWAVDKMLREETRVLTDDVIFEVASNGTRVIDTIIKNRTYMSITGSKIKIDQYGDSEGNFSVLAYKPHKWNNSNNMPCNYHMVPVAYFHQGEEHPEYKLINGSIDWPSGGEKPADEPMCGFANELCKKDDTHYTSTVAAVVLGVLLFCSGVITMSIYRKWKIELEIEGLLWKIDPNEIKGYSGNEIVSSPSKVSLMSAQSYGSRWTNQFVTSTGRLRGAVVRIKELKFPRKRDISREIMKEMRLLRELRHDNINSFIGASVEPTRILLVTDYCAKGSLYDIIENEDIKLDDLFIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQCAENESIGEHQHYRNQLWRAPELLRNHIHGSQKGDVYAFAIIMYEIFSRKGPFGQINFEPKEIVDYVKKLPLKGEDPFRPEVESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKMRGGKTKNIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTGANENAIQKKLVDMMDMPPPLFSRPRKSPKLNPDSRQPSIQAMHFCGTGSRRQSTVPRAMDGESTYSLQGSVRESPRMVSKRDRDRERPPINGLGAGHFVGGALLESAQASLSTLNHSETNETNCDMDGGSGGVSGSGSGLVRQPNALHKPLAMVRPHRIISAAQLPQLGDNDDDSADTLLRESRSLDPMPMQQLRKRHDRVKLPPSKLSKNNSRSLDTGVSLISGNPNGEVHSSQLDLDNEMTANPVDATDGYDDELGLLMRHDNGQLPALRYSGSFPNAQISIVPTGRSAGGGGGGREGGGSNCAKHLNNNCNGGVNVEDDLESPLLQRQASLSVPPEEMLAHNKRWHSLEHMDGPGGHGGNSVSYAADIDNRHPGDLDFFSGSSNQHHRSKAAGGSKLTNWMTNIFKGNGVRSGEARRVGILPSGVHGARTGFTDMAASAAARDRESIV

3D Structure

Not available now!

Publication

1.	McNeil L, Chinkers M, Forte M.; Identification, characterization, and developmental regulation of a receptor guanylyl cyclase expressed during early stages of Drosophila development.; J Biol Chem. 1995 Mar 31;270(13):7189-96.

Salivary Protein Card