Salivary Protein Card
Accession: Sp001738 Tyrosine-protein kise Shark [Drosophila melanogaster]
Basic info
| Organism | Drosophila melanogaster |
| Taxonomy | Insecta > Diptera > Drosophilidae > Drosophila > Drosophila melanogaster |
| Protein Description | Tyrosine-protein kise Shark |
| Mass Weight | 104271.978 |
| Isoelectric Point | 6.533 |
Annotation
| Function | Following axon injury, required for recruitment of drpr and glial cells to severed axons and for glial clearance of severed axons from the central nervous system (PubMed:18432193). Together with Src42a and drpr, promotes the migration of macrophages to sites of wounding as part of a sigling cascade where Scr42a detects production of hydrogen peroxide at wound sites which triggers phosphorylation of drpr and subsequent recruitment and activation of shark (PubMed:26028435). May be involved in sigl transduction on the apical surface of ectodermal epithelial cells, regulating their polarity during invagition (PubMed:7892198). Crumbs (crb) may be the intracellular sigl (PubMed:7892198). | ||
| Pfam |
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Features
| Feature key | Position | Length |
| Chain | 1-939 | 939 |
Sequence
3D Structure
Not available now!
Publication
| 1. |
Ferrante AW Jr, Reinke R, Stanley ER.; Shark, a Src homology 2, ankyrin repeat, tyrosine kise, is expressed on the apical surfaces of ectodermal epithelia.; Proc tl Acad Sci U S A. 1995 Mar 14;92(6):1911-5. 7892198 |