Salivary Protein Card
Accession: Sp001808 Homeobox protein homothorax [Drosophila melanogaster]
Basic info
| Organism | Drosophila melanogaster |
| Taxonomy | Insecta > Diptera > Drosophilidae > Drosophila > Drosophila melanogaster |
| Protein Description | Homeobox protein homothorax |
| Mass Weight | 52783.908 |
| Isoelectric Point | 5.894 |
Annotation
| Function | All isoforms are required for patterning of the embryonic cuticle. Acts with exd to delimit the eye field and prevent ippropriate eye development. Isoforms that carry the homeodomain are required for proper localization of chordotol organs within the peripheral nervous system and antenl identity; required to activate antenl-specific genes, such as sal and to repress the leg-like expression of dac. Necessary for the nuclear localization of the essential HOX cofactor, extradenticle (exd). Both necessary and sufficient for inner photoreceptors to adopt the polarization-sensitive dorsal rim area (DRA) of the eye fate instead of the color-sensitive default state. This occurs by increasing rhabdomere size and uncoupling R7-R8 communication to allow both cells to express the same opsin rather than different ones as required for color vision. | ||
| Pfam |
|
Features
| Feature key | Position | Length |
| Chain | 1-487 | 487 |
Sequence
3D Structure
Not available now!
Publication
| 1. |
Rieckhof GE, Casares F, Ryoo HD, Abu-Shaar M, Mann RS.; Nuclear translocation of extradenticle requires homothorax, which encodes an extradenticle-related homeodomain protein.; Cell. 1997 Oct 17;91(2):171-83. 9346235 |