Salivary Protein Card
Accession: Sp001831 RAC serine/threonine-protein kise [Drosophila melanogaster]
Basic info
| Organism | Drosophila melanogaster |
| Taxonomy | Insecta > Diptera > Drosophilidae > Drosophila > Drosophila melanogaster |
| Protein Description | RAC serine/threonine-protein kise |
| Mass Weight | 68483.749 |
| Isoelectric Point | 5.851 |
Annotation
| Function | Serine/threonine kise involved in various developmental processes (PubMed:9601646, PubMed:10587646, PubMed:10962553, PubMed:11740943, PubMed:12172554, PubMed:11872800, PubMed:14525946, PubMed:12893776, PubMed:15466161, PubMed:15712201). During early embryogenesis, acts as a survival protein (PubMed:9601646, PubMed:10962553). During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determition (PubMed:11740943). Also regulates tracheal cell migration (PubMed:11740943, PubMed:14525946). Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor (PubMed:10587646, PubMed:10962553, PubMed:11752451, PubMed:12893776, PubMed:25329475, PubMed:29025897, PubMed:24603715). Controls follicle cell size during oogenesis (PubMed:15712201). May also stimulate cell growth by phosphorylating Gig/Tsc2 and ictivating the Tsc complex (PubMed:12172554, PubMed:15466161). Dephosphorylation of Ser-586 by Phlpp triggers apoptosis and suppression of tumor growth (PubMed:10962553). | ||
| Pfam |
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Features
| Feature key | Position | Length |
| Chain | 1-611 | 611 |
Sequence
3D Structure
Not available now!
Publication
| 1. |
Franke TF, Tartof KD, Tsichlis PN.; The SH2-like Akt homology (AH) domain of c-akt is present in multiple copies in the genome of vertebrate and invertebrate eucaryotes.; Cloning and characterization of the Drosophila melanogaster c-akt homolog Dakt1. Oncogene. 1994 Jan;9(1):141-8. PMID8302573 |