Salivary Protein Card
Accession: Sp001907 Major royal jelly protein 1 [Apis mellifera]
Basic info
| Organism | Apis mellifera |
| Taxonomy | Insecta > Hymenoptera > Apidae > Apis > Apis mellifera |
| Protein Description | Major royal jelly protein 1 |
| Mass Weight | 48885.536 |
| Isoelectric Point | 5.099 |
Annotation
| Function | [Major royal jelly protein 1]: Induces the differentiation of honeybee larvae into queens through an Egfr-mediated sigling pathway. Promotes body size increase by activating p70 S6 kise, stimulates ovary development by augmenting the titer of vitellogenin (Vg) and juvenile hormone, and reduces developmental time by increasing the activity of mitogen-activated protein kise and inducing the 20-hydroxyecdysone protein (20E). Most abundant protein found in the royal jelly which is the food of the queen honey bee larva. The royal jelly determines the development of the young larvae and is responsible for the high reproductive ability of the honeybee queen. {ECO:0000269|PubMed:21516106}.; [Jellein-1]: Has antibacterial activity against the Gram-positive bacteria S.aureus ATCC 6535, S.saprophyticus and B.subtilis CCT2471, and the Gram-negative bacteria E.coli CCT1371, E.cloacae ATCC 23355, K.pneumoniae ATCC 13883 and P.aeruginosa ATCC 27853, and antifungal activity against C.albicans. Lack cytolytic activity and does not induce rat peritoneal mast cell degranulation. {ECO:0000269|PubMed:15203237}.; [Jellein-2]: Has antibacterial activity against the Gram-positive bacteria S.aureus ATCC 6535, S.saprophyticus and B.subtilis CCT2471, and the Gram-negative bacteria E.coli CCT1371, E.cloacae ATCC 23355, K.pneumoniae ATCC 13883 and P.aeruginosa ATCC 27853, and antifungal activity against C.albicans. Lack cytolytic activity and does not induce rat peritoneal mast cell degranulation. {ECO:0000269|PubMed:15203237}.; [Jellein-4]: Lacks antibacterial and antifungal activity. Lacks cytolytic activity and does not induce rat peritoneal mast cell degranulation. {ECO:0000269|PubMed:15203237} | ||
| Pfam |
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Features
| Feature key | Position | Length |
| Signal Peptide | 1-19 | 19 |
| Chain | 20-432 | 413 |
Sequence
3D Structure
Not available now!
Publication
| 1. |
Feng M, Fang Y, Han B, Zhang L, Lu X, Li J.; Novel aspects of understanding molecular working mechanisms of salivary glands of worker honeybees (Apis mellifera) investigated by proteomics and phosphoproteomics.; J Proteomics. 2013 Jan Jul 11;87:1-15. |