Venom Protein Card
Accession: Add00025 Secapin-2 [Apis mellifera]
Basic info
| Organism | Apis mellifera |
| Taxonomy | Insecta > Hymenoptera > Apidae > Apis > Apis mellifera |
| Protein Description | Secapin-2 |
| Mass Weight | 8763.37 Da |
| Isoelectric Point | 9.45 |
| Expression | Highly expressed in venom gland |
Annotation
| Function | Serine protease inhibitor which exhibits antifibrinolytic, antielastolytic and antimicrobial activities (By similarity). Displays antimicrobial activity against bacteria and fungi (By similarity). Likely functions in the innate immune response to microbial infection and possibly in the venom, as an antifibrinolytic agent (By similarity). Induces hyperalgesia and edema mediated by leukotrienes when injected into mice. Does not induce hemolytic activity, mast cell degranulation, or chemotactic activity for polymorphonucleated leukocytes (PMNL). | ||
| Pfam |
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Features
| Feature key | Position | Length |
| Signal Peptide | 1..32 | 32 |
| Propeptide | 33..52 | 20 |
| Peptide | 53..77 | 25 |
Sequence
Publication
| 1. |
Hou C.S., Guo L.Q., Wang J.R., You L.F., Lin J.F., Wang C.S., Wu W.H., Wang T.; Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases. |
| 2. |
Mourelle D., Brigatte P., Bringanti L.D., De Souza B.M., Arcuri H.A., Gomes P.C., Baptista-Saidemberg N.B., Ruggiero Neto J., Palma M.S.; "Hyperalgesic and edematogenic effects of Secapin-2, a peptide isolated from Africanized honeybee (Apis mellifera) venom."; Peptides 59:42-52(2014). |