Venom Protein Card
Accession: Pre00069 Kunitz-type serine protease inhibitor Bi-KTI [Bombus ignitus]
Basic info
| Organism | Bombus ignitus |
| Taxonomy | Insecta > Hymenoptera > Apidae > Bombus > Bombus ignitus |
| Protein Description | Kunitz-type serine protease inhibitor Bi-KTI |
| Mass Weight | 8966.31 Da |
| Isoelectric Point | 6.23 |
| Expression | Highly expressed in venom gland |
Annotation
| Function | Serine protease inhibitor that inhibits plasmin (IC(50)=43.53 nM, Ki=3.6 nM). Acts as an antifibrinolytic agent. May act in a cooperative manner with the serine protease Bi-VSP (AC B5U2W0) to promote the spread of bee venom under anti-bleeding conditions. | ||
| Pfam |
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Features
| Feature key | Position | Length |
| Signal Peptide | 1..24 | 24 |
| Chain | 25..82 | 58 |
Sequence
Publication
| 1. |
Choo Y.M., Lee K.S., Yoon H.J., Qiu Y., Wan H., Sohn M.R., Sohn H.D., Jin B.R.; "Antifibrinolytic role of a bee venom serine protease inhibitor that acts as a plasmin inhibitor."; PLoS ONE 7:E32269-E32269(2012). |