Venom Protein Card
Accession: Pre05162 Hyaluronidase [Apis mellifera]
Basic info
| Organism | Apis mellifera |
| Taxonomy | Insecta > Hymenoptera > Apidae > Apis > Apis mellifera |
| Protein Description | Hyaluronidase |
| Mass Weight | 44259.16 Da |
| Isoelectric Point | 8.67 |
| Expression | Highly expressed in venom gland |
Annotation
| Function | Hydrolyzes high molecular weight hyaluronic acid to produce small oligosaccharides.The hyaluronidase from bee venom glands exhibited significant homology to PH-20, a membrane protein of guinea pig sperm involved in sperm-egg adhesion. These structural data support the long-held view that hyaluronidases play a role in fertilization. | ||
| Pfam |
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Features
| Feature key | Position | Length |
| Signal Peptide | 1..28 | 28 |
| Propeptide | 29..33 | 5 |
| Chain | 34..382 | 349 |
Sequence
Publication
| 1. |
Gmachl M., Kreil G.; "Bee venom hyaluronidase is homologous to a membrane protein of mammalian sperm."; Proc. Natl. Acad. Sci. U.S.A. 90:3569-3573(1993). |
| 2. |
Jacobson R.S., Hoffman D.R., Kemeny D.M.; "The cross-reactivity between bee and vespid hyaluronidases has a structural basis."; J. Allergy Clin. Immunol. 89:292-292(1991). |
| 3. |
Kubelka V., Altmann F., Marz L.; "The asparagine-linked carbohydrate of honeybee venom hyaluronidase."; Glycoconj. J. 12:77-83(1995). |
| 4. |
Kolarich D., Altmann F.; "N-glycan analysis by matrix-assisted laser desorption/ionization mass spectrometry of electrophoretically separated nonmammalian proteins: application to peanut allergen Ara h 1 and olive pollen allergen Ole e 1."; Anal. Biochem. 285:64-75(2000). |
| 5. |
Markovic-Housley Z., Miglierini G., Soldatova L., Rizkallah P.J., Mueller U., Schirmer T.; "Crystal structure of hyaluronidase, a major allergen of bee venom."; Structure 8:1025-1035(2000). |